While I have only played in one major live tournament, I did last until a few hands before the end of day 1. IMO, it was not very similar to playing a bunch of online ones.
It also wasn't even remotely gruelling. It's just not that hard to concentrate for eight or 10 hours, especially since it's not constant. At least half the time is spent shuffling and dealing, and even though you do watch what goes on, it's not something that takes brain-straining effort to do.
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